PTP1B-IN-19
PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.
Product Specifications
CAS Number
[2848581-83-7]
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ptp1b-in-19.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1C(O)=O)CSC2=NC3=C(N2)C=CC(OC4=C5C=CC=CC5=CC=C4)=C3
Molecular Formula
C26H19N3O4S
Molecular Weight
469.51
References & Citations
[1]Mara Ibeth Campos-Almazán, et al. Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors. Bioorg Med Chem. 2021 Oct 15
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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