HIV-1 inhibitor-18

HIV-1 inhibitor-18 (compound II-13c) is a potent HIV-1 capsid inhibitor with an EC50 value of 5.14 μM for HIV-1 NL4-3. HIV-1 inhibitor-18 has certain cytotoxicity (MT-4 cells CC50 >9.51) [1].

Product Specifications

CAS Number

[2764787-56-4]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-18.html

Solubility

10 mM in DMSO

Smiles

O=C(N(C1=CC=C(OC)C=C1)C)[C@@H](NS(=O)(CC(N(C2=CC=C(OC)C=C2)C)=O)=O)CC3=CC=CC=C3

Molecular Formula

C27H31N3O6S

Molecular Weight

525.62

References & Citations

[1]Li J, et al. Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors. Bioorg Med Chem. 2021;48:116414.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HIV-1

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