PTP1B-IN-16

PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.

Product Specifications

CAS Number

[2848581-86-0]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ptp1b-in-16.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C=C1)C(O)=O)CSC2=NC3=C(N2)C=C(C(OC4=CC5=CC=CC=C5C=C4)=C3)Cl

Molecular Formula

C26H18ClN3O4S

Molecular Weight

503.96

References & Citations

[1]Mara Ibeth Campos-Almazán, et al. Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors. Bioorg Med Chem. 2021 Oct 15