D5261

D5261 is a potent, type III allosteric tropomyosin-related kinase A (TrkA) inhibitor[1].

Product Specifications

CAS Number

1574574-57-4

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/d5261.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=C(C=C1)C(NC2=CN=C(C=C2)N3CCN(C3=O)C4CCCC4)=O)N5CCCC5=O

Molecular Formula

C25H29N5O3

Molecular Weight

447.53

References & Citations

[1]Jing Guo, et al. Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies. Eur J Med Chem. 2022 Jan 15;228:114022.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TrkA

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