ATM Inhibitor-4
ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC50 of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability[1].
Product Specifications
CAS Number
[2769140-74-9]
UNSPSC
12352005
Target
ATM/ATR; mTOR; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
COCCN1C(N(C2=C1C3=CC(C4=CC=C(C=C4)NC(NCCN5CC(C5)F)=O)=CC=C3N=C2)C)=O
Molecular Formula
C26H29FN6O3
Molecular Weight
492.55
References & Citations
[1]Dimitrov T, et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem. 2022 May 5;235:114234.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM; mTOR; PI3K
Curated Selection
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