PF-07038124

PF-07038124 is a PDE4 inhibitor with an IC50 of 0.5 nM for PDE4B2. PF-07038124 shows inhibitory activities against IL-13, IL4, and IFNγ (IC50=125, 4.1, 1.06 nM, respectively) . PF-07038124 can be used for research of atopic dermatitis and plaque psoriasis[1][2].

Product Specifications

CAS Number

[2415085-44-6]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pf-07038124.html

Solubility

10 mM in DMSO

Smiles

CCCOC1=C(OC)C=CC(C2=CN=CC([C@@]3([H])CB(OC3)O)=C2)=C1

Molecular Formula

C18H22BNO4

Molecular Weight

327.18

References & Citations

[1]Boron containing pde4 inhibitors.WO2020070651A1.|[2]Eichenfield LF, et al. Efficacy and Safety of PF-07038124 in Patients With Atopic Dermatitis and Plaque Psoriasis: A Randomized Clinical Trial. JAMA Dermatol. 2024 Feb 1;160 (2) :156-163.