A2A receptor antagonist 2
A2A receptor antagonist 2 (Compound 57) is a potent, highly selective adenosine A2A receptor (A2AR) antagonist with an IC50 of 8.3 nM[1].
Product Specifications
CAS Number
2767206-20-0
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a2a-receptor-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CC=C(O2)C)=C3C(N(C(C=N3)=O)CCN4CCN(C[C@@H]4C)C5=CC=C(C=C5F)OC)=N1
Molecular Formula
C25H28FN7O3
Molecular Weight
493.53
References & Citations
[1]Fazhi Yu, et al. Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7 (8H) -one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J Med Chem. 2022 Mar 10;65 (5) :4367-4386.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR)
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E-EL-H0951-01 24 Tests
Human TLR-2 (Toll-like Receptor 2) ELISA Kit
Sign In for Pricing
View Details E-EL-H0951-02 48 Tests
Human TLR-2 (Toll-like Receptor 2) ELISA Kit
Sign In for Pricing
View Details E-EL-H0951-03 96 Tests
Human TLR-2 (Toll-like Receptor 2) ELISA Kit
Sign In for Pricing
View Details 