A2A receptor antagonist 2
A2A receptor antagonist 2 (Compound 57) is a potent, highly selective adenosine A2A receptor (A2AR) antagonist with an IC50 of 8.3 nM[1].
Product Specifications
CAS Number
2767206-20-0
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a2a-receptor-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CC=C(O2)C)=C3C(N(C(C=N3)=O)CCN4CCN(C[C@@H]4C)C5=CC=C(C=C5F)OC)=N1
Molecular Formula
C25H28FN7O3
Molecular Weight
493.53
References & Citations
[1]Fazhi Yu, et al. Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7 (8H) -one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J Med Chem. 2022 Mar 10;65 (5) :4367-4386.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR)
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