SP inhibitor 1

SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, Mpro and PLpro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250antiviral activity[1].

Product Specifications

CAS Number

[2766185-81-1]

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sp-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

COC(C1=CC=C2C(C(CN(CC3=CC=CC=C3)CCC4=CC=C(C=C4)C5=CC=CC=C5)=CN2CC(C)C)=C1)=O

Molecular Formula

C36H38N2O2

Molecular Weight

530.70

References & Citations

[1]Veronica Di Sarno, et al. Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization. Eur J Med Chem. 2021 Dec 15;226:113863.