PARP-1-IN-1

PARP-1-IN-1 is a high selective and orally active PARP-1 inhibitor (IC50=0.96 nM) . PARP-1-IN-1 has well tolerance and remarkable single dose activity in the MDA-MB-436 xenotransplantation model[1].

Product Specifications

CAS Number

[2763840-83-9]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp-1-in-1.html

Solubility

10 mM in DMSO

Smiles

NC1CCN(CC1)CC2=CC(C3=C4CCNC(C5=C4C(N3)=CC(F)=C5)=O)=CC=C2

Molecular Formula

C23H25FN4O

Molecular Weight

392.47

References & Citations

[1]Yu J, et al. Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2. Eur J Med Chem. 2022;227:113898.