Antifungal agent 22
Product Specifications
UNSPSC Description
Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity[1].
Target Antigen
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antifungal-agent-22.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C2C3=C(C(CC2)NCCC4CCOCC4)C=CS3)=CC=C1Cl.[H]Cl
Molecular Weight
446.86
References & Citations
[1]Li W, Yun Z, Ji C, et al. Discovery of Novel Sertraline Derivatives as Potent anti-<i>Cryptococcus</i> Agents.J Med Chem. 2022 Mar 6;10.1021/acs.jmedchem.1c01845.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144632/Antifungal-agent-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144632/
Clinical Information
No Development Reported
CAS Number
9007-83-4
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