Antifungal agent 22
Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity[1].
Product Specifications
CAS Number
[2640054-39-1]
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antifungal-agent-22.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C2C3=C(C(CC2)NCCC4CCOCC4)C=CS3)=CC=C1Cl.[H]Cl
Molecular Formula
C21H26Cl3NOS
Molecular Weight
446.86
References & Citations
Cryptococcus
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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