Asn-Pro-Val-PABC-MMAE (TFA)
Asn-Pro-Val-PABC-MMAE TFA (compound 8) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
2893871-67-3
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/asn-pro-val-pabc-mmae-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](C(C)C)NC([C@H]4N(CCC4)C([C@@H](N)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C63H97F3N10O15
Molecular Weight
1291.50
References & Citations
[1]Mohamed Amar IA, et al. Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate. Eur J Med Chem. 2022 Feb 5;229:114063.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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