Neuropeptide Y Y1 receptor antagonist 1

Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y1 receptor (Y1R), with a Ki of 0.19 nM[1].

Product Specifications

CAS Number

[2773476-40-5]

UNSPSC

12171500

Target

Neuropeptide Y Receptor

Type

Dye Reagents

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/neuropeptide-y-y1-receptor-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(C(NCCCCOC2=CC=CC([C@@H](C(N[C@H](CCCN/C(N)=N\C(NCCNC(CC)=O)=O)C(NCC3=CC=C(C=C3)O)=O)=O)C4=CC=CC=C4)=C2)=O)=CC=C1C5=C6C=C/C(C=C6OC7=C5C=CC(N(C)C)=C7)=[N+](C)/C)[O-]

Molecular Formula

C62H70N10O10

Molecular Weight

1115.28

References & Citations

[1]Müller C, et, al. Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y 1 Receptor. J Med Chem. 2022 Mar 24;65 (6) :4832-4853.