AGD-0182

AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10[1]. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1835700-14-5]

UNSPSC

12352005

Target

ADC Payload; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/agd-0182.html

Solubility

10 mM in DMSO

Smiles

CN[C@@H](C(C)C)C(N[C@@H]([C@H](C)N=[N+]=[N-])C(N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(N1[C@@H](CCC1)[C@H](OC)[C@@H](C)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O)OC)=O)=O

Molecular Formula

C38H63N9O7

Molecular Weight

757.96

References & Citations

[1]Snyder JT, et al. Metabolism of an Oxime-Linked Antibody Drug Conjugate, AGS62P1, and Characterization of Its Identified Metabolite. Mol Pharm. 2018;15 (6) :2384-2390.