PF-4778574
PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
Product Specifications
CAS Number
[1219633-99-4]
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-4778574.html
Solubility
10 mM in DMSO
Smiles
O=S(N[C@@H](CCOC1)[C@H]1C(C=C2)=CC=C2C3=CC=C(C#N)S3)(C(C)C)=O
Molecular Formula
C19H22N2O3S2
Molecular Weight
390.52
References & Citations
[1]Roberts BM, et al. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav Brain Res. 2010 Sep 1;212 (1) :41-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Curated Selection
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