PF-4778574

PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.

Product Specifications

CAS Number

[1219633-99-4]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PF-4778574.html

Solubility

10 mM in DMSO

Smiles

O=S(N[C@@H](CCOC1)[C@H]1C(C=C2)=CC=C2C3=CC=C(C#N)S3)(C(C)C)=O

Molecular Formula

C19H22N2O3S2

Molecular Weight

390.52

References & Citations

[1]Roberts BM, et al. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav Brain Res. 2010 Sep 1;212 (1) :41-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AMPA Receptor

Curated Selection

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