HE-S2
HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity[1].
Product Specifications
CAS Number
[2939851-67-7]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; PD-1/PD-L1; Toll-like Receptor (TLR)
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/he-s2.html
Solubility
10 mM in DMSO
Smiles
C[C@H](COC(NC1=CC=C(C[N+](C)(C)CC2=CC=C(CC3=CC=C(N=C(N)N=C4NCCCC)C4=N3)C=C2)C=C1)=O)SSC5=NC=C([N+]([O-])=O)C=C5.[H]C([O-])=O
Molecular Formula
C38H45N9O6S2
Molecular Weight
787.95
References & Citations
[1]He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64 (21) :15716-15726.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
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