HE-S2
HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity[1].
Product Specifications
CAS Number
2939851-67-7
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; PD-1/PD-L1; Toll-like Receptor (TLR)
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/he-s2.html
Solubility
10 mM in DMSO
Smiles
C[C@H](COC(NC1=CC=C(C[N+](C)(C)CC2=CC=C(CC3=CC=C(N=C(N)N=C4NCCCC)C4=N3)C=C2)C=C1)=O)SSC5=NC=C([N+]([O-])=O)C=C5.[H]C([O-])=O
Molecular Formula
C38H45N9O6S2
Molecular Weight
787.95
References & Citations
[1]He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64 (21) :15716-15726.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
SDCCAG1, NT (NEMF, SDCCAG1, Nuclear export mediator factor NEMF, Antigen NY-CO-1, Serologically defined colon cancer antigen 1)
