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Xanthine oxidase-IN-5

Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model[1].

Product Specifications

CAS Number

[2276711-87-4]

UNSPSC

12352005

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/xanthine-oxidase-in-5.html

Solubility

10 mM in DMSO

Smiles

O=CC1=CC(F)=CC=C1OCC2=CN(CC3=CC=CC(OC)=C3)N=N2

Molecular Formula

C18H16FN3O3

Molecular Weight

341.34

References & Citations

[1]Zhang TJ, Zhang Y, Zhang ZH, et al. Discovery of 4- (phenoxymethyl) -1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2022;60:128582.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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