TRK-IN-12
TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM) . TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM) . TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line[1].
Product Specifications
CAS Number
2823342-34-1
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-12.html
Solubility
10 mM in DMSO
Smiles
CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
Molecular Formula
C18H19ClFN5O3S
Molecular Weight
439.89
References & Citations
[1] Li P, et al. Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors [published correction appears in Bioorg Med Chem Lett. 2022 Jan 15;56:128502]. Bioorg Med Chem Lett. 2021;53:128409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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