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TRK-IN-12

TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM) . TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM) . TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line[1].

Product Specifications

CAS Number

2823342-34-1

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trk-in-12.html

Solubility

10 mM in DMSO

Smiles

CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O

Molecular Formula

C18H19ClFN5O3S

Molecular Weight

439.89

References & Citations

[1] Li P, et al. Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors [published correction appears in Bioorg Med Chem Lett. 2022 Jan 15;56:128502]. Bioorg Med Chem Lett. 2021;53:128409.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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