PI3K-IN-29
PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 μM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].
Product Specifications
CAS Number
2768005-77-0
UNSPSC
12352005
Target
Akt; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-29.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O
Molecular Formula
C27H22ClN7O3S
Molecular Weight
560.03
References & Citations
[1]Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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