MTOR/HDAC6-IN-1
MTOR/HDAC6-IN-1 is a potent mTOR and HDAC6 dual inhibitor (IC50s of 133.7 nM and 56 nM for mTOR and HDAC6, respectively) . mTOR/HDAC6-IN-1 can induce significant autophagy, apoptosis and suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breast cancer (TNBC) [1].
Product Specifications
CAS Number
[2986747-52-6]
UNSPSC
12352005
Target
Apoptosis; Autophagy; HDAC; mTOR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-hdac6-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2=NC(C3=CC=C(C=C3)C(NO)=O)=NC4=CC(Cl)=CC=C42
Molecular Formula
C20H20ClN5O2
Molecular Weight
397.86
References & Citations
[1]Yao D, et al. Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells. Bioorg Med Chem Lett. 2021;47:128204.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6; mTOR
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