NSC114126
NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK) . NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
24909-18-0
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc114126.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC=C(CC)C=C2)=C(O)C(C(C3=CC=C(CC)C=C3)=C1O)=O
Molecular Formula
C22H20O4
Molecular Weight
348.39
References & Citations
[1]Jiwacharoenchai N, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022;58:128524.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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