NSC381467
Product Specifications
UNSPSC Description
NSC381467 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC381467 has strong antiproliferative activities. NSC381467 has the potential for the research of cancer diseases[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc381467.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC2=C1C(C3=C(C4=C([C@H]([C@@H]3O)O)C=C(C=C4O)CO)C2=O)=O
Molecular Weight
368.34
References & Citations
[1]Jiwacharoenchai N, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022;58:128524.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144444/NSC381467-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144444/
Clinical Information
No Development Reported
CAS Number
1033006-96-0
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