NSC381467

NSC381467 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK) . NSC381467 has strong antiproliferative activities. NSC381467 has the potential for the research of cancer diseases[1].

Product Specifications

CAS Number

[1033006-96-0]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc381467.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=CC2=C1C(C3=C(C4=C([C@H]([C@@H]3O)O)C=C(C=C4O)CO)C2=O)=O

Molecular Formula

C20H16O7

Molecular Weight

368.34

References & Citations

[1]Jiwacharoenchai N, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022;58:128524.