PD-1/PD-L1-IN-16
PD-1/PD-L1-IN-16 (Compound M23) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 53.2 nM. PD-1/PD-L1-IN-16 has the potential for the research of tumor immunoresearch[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-16.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CN=CC(COC2=CC(C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=O)=CC=C2CN6CC[C@H](C(O)=O)C6)=C1
Molecular Formula
C34H30N4O4
Molecular Weight
558.63
References & Citations
[1]Meng Y, et al. Discovery of 4-phenylindolines containing a (5-cyanopyridin-3-yl) methoxy moiety as potent inhibitors of the PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2022 May 1;63:128647
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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