PD-1/PD-L1-IN-16

PD-1/PD-L1-IN-16 (Compound M23) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 53.2 nM. PD-1/PD-L1-IN-16 has the potential for the research of tumor immunoresearch[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-16.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CN=CC(COC2=CC(C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=O)=CC=C2CN6CC[C@H](C(O)=O)C6)=C1

Molecular Formula

C34H30N4O4

Molecular Weight

558.63

References & Citations

[1]Meng Y, et al. Discovery of 4-phenylindolines containing a (5-cyanopyridin-3-yl) methoxy moiety as potent inhibitors of the PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2022 May 1;63:128647