ALK5-IN-9
ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5) . ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease[1].
Product Specifications
CAS Number
2489611-06-3
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-9.html
Solubility
10 mM in DMSO
Smiles
OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1
Molecular Formula
C29H35F3N6O3
Molecular Weight
572.62
References & Citations
[1]Wang Z, et al. Synthesis and biological evaluation of 4- (pyridine-4-oxy) -3- (tetrahydro-2H-pyran-4-yl) -pyrazole derivatives as novel, potent of ALK5 receptor inhibitors. Bioorg Med Chem Lett. 2022;61:128552.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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