Bcl-2/Mcl-1-IN-3

Bcl-2/Mcl-1-IN-3 (compound 1) is a Bcl-2/Mcl-1 inhibitor, with Kis of 0.14 μM and 0.23 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-3 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2088981-53-5]

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcl-2-mcl-1-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=CC=C1COC2=CC=CC3=C2C=CN3CCCOC4=CC(C)=C(Cl)C(C)=C4

Molecular Formula

C27H26ClNO4

Molecular Weight

463.95

References & Citations

[1]Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2- (1H-indol-4-yl) benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215.