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Bcl-2/Mcl-1-IN-1

Bcl-2/Mcl-1-IN-1 (compound 3) is a Bcl-2/Mcl-1 inhibitor, with Kis of 1.19 μM and 4.53 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-1 can be used for the research of cancer[1].

Product Specifications

CAS Number

2673361-08-3

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcl-2-mcl-1-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=CC=C1C2=CC=CC3=C2C=CN3CCCOC4=C5C=CC=CC5=CC=C4

Molecular Formula

C28H23NO3

Molecular Weight

421.49

References & Citations

[1]Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2- (1H-indol-4-yl) benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Bcl-2; Mcl-1

Frequently Asked Questions

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