Bcl-2/Mcl-1-IN-2
Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/Mcl-1 inhibitor, with Kis of 0.88 μM and 4.70 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer[1].
Product Specifications
CAS Number
2673361-07-2
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-mcl-1-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=CC=C1C2=CC=CC3=C2C=CN3CCCOC4=CC(C)=C(Cl)C(C)=C4
Molecular Formula
C26H24ClNO3
Molecular Weight
433.93
References & Citations
[1]Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2- (1H-indol-4-yl) benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Mcl-1
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