CD33 splicing modulator 1 (hydrochloride)
Product Specifications
UNSPSC Description
CD33 splicing modulator 1 (Compound 1) hydrochloride is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 hydrochloride increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 hydrochloride has the potential for the research of neurodegenerative disease including Alzheimer's disease[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cd33-splicing-modulator-1-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CC1=CN2N=CC(C3=CC=C(C=C3F)C(N([C@@H]4CCCNC4)C5=C(C=CC=N5)C)=O)=C2N=C1.[H]Cl
Molecular Weight
480.96
References & Citations
[1]Chappie TA, et al. Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators. ACS Med Chem Lett. 2022;13(1):55-62.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144399A/CD33-splicing-modulator-1-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144399A/
Clinical Information
No Development Reported
CAS Number
2762547-06-6
Curated Selection
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