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HAChE/Aβ1-42-IN-1

HAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD) [1].

Product Specifications

CAS Number

2761149-17-9

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hache-aβ1-42-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NNC2=NC=CC=C21)CCN3CCN(CC3)CC4=CC=CC=C4

Molecular Formula

C20H24N6O

Molecular Weight

364.44

References & Citations

[1]Waly OM, et al. Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents. Eur J Med Chem. 2022;231:114152.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE

Frequently Asked Questions

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