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DHODH-IN-20

DHODH-IN-20 (Compound 133) is a potent inhibitor of DHODH. DHODH is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-20 inhibits tumor growth. DHODH-IN-20 has the potential for the research of acute myelogenous leukemia[1].

Product Specifications

CAS Number

[2639835-02-0]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dhodh-in-20.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC=C1C)C2=CC(F)=C(C3=CN(C)C(C(C)(O)C)=N3)C=C2O[C@@H](C)C(F)(F)F

Molecular Formula

C24H25F4N3O3

Molecular Weight

479.47

References & Citations

[1]Sabnis RW. Biaryl Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML) . ACS Med Chem Lett. 2022;13 (2) :158-159.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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