Antitumor agent-44

Antitumor agent-44 (Compound 5n) disrupts the mitochondrial homeostasis, induces cell cycle arrest and apoptosis in human adenocarcinoma cells. Antitumor agent-44 (Compound 5n) possesses good anti-tumor activity in a lung-cancer-cell xenograft mice model[1].

Product Specifications

CAS Number

[1811548-74-9]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-44.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(OCO2)C2=C1)C3=CC=CC4=C3N(C5=NC=CC=N5)C6=C4C=CC=C6

Molecular Formula

C24H15N3O3

Molecular Weight

393.39

References & Citations

[1]Xiao-Xuan Su, et al. Design, synthesis, and evaluation of 9- (pyrimidin-2-yl) -9H-carbazole derivatives disrupting mitochondrial homeostasis in human lung adenocarcinoma. Eur J Med Chem. 2022 Mar 15;232:114200.