PARP1/BRD4-IN-1
PARP1/BRD4-IN-1 is a potent and high selective PARP1/BRD4 inhibitor (IC50s of 49 and 202 nM in PARP1 and BRD4, respectively) . PARP1/BRD4-IN-1 represses the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells[1].
Product Specifications
CAS Number
2758117-74-5
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; Epigenetic Reader Domain; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp1-brd4-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC2=C1NC(CN3C(N(C)C4=CC=C(C5=C(C)ON=C5C)C=C4C3C6=CC=CC=C6)=O)=N2)N
Molecular Formula
C29H26N6O3
Molecular Weight
506.56
References & Citations
[1]Huang SH, et al. Design, synthesis and mechanism studies of novel dual PARP1/BRD4 inhibitors against pancreatic cancer. Eur J Med Chem. 2022;230:114116.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; PARP1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Polyclonal Endosialin/CD248/TEM1 Antibody [mFluor Violet 450 SE]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP1-77311MFV450 0.1 mL
Rabbit Polyclonal Endosialin/CD248/TEM1 Antibody [mFluor Violet 450 SE]
Sign In for Pricing
View Details 
orb898732 100 µL
Human Fibrinogen Mouse Monoclonal Antibody (PE-Cy7)
Sign In for Pricing
View Details ABC-SC109G 1 Vial
BALB/c Mouse Bone Marrow-Derived Endothelial Progenitor Cells
Sign In for Pricing
View Details