DNA crosslinker 3 (dihydrochloride)

DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer[1].

Product Specifications

CAS Number

[2761734-21-6]

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dna-crosslinker-3-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CC(CNC(N)=N)=NN1CC2=CC=C(C=C2)CNC(N)=N.[H]Cl.[H]Cl

Molecular Formula

C15H22Cl2N8O

Molecular Weight

401.29

References & Citations

[1]Costas-Lago MC, et al. Novel Pyridazin-3 (2H) -one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity. ACS Med Chem Lett. 2022;13 (3) :463-469. Published 2022 Feb 10.