DNA crosslinker 2 (dihydrochloride)
DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer[1].
Product Specifications
CAS Number
2761734-25-0
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dna-crosslinker-2-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC(NCC1=CC=C(CN2C(C=C(CNC(N)=N)C=N2)=O)C=C1)=N.[H]Cl.[H]Cl
Molecular Formula
C15H22Cl2N8O
Molecular Weight
401.29
References & Citations
[1]Costas-Lago MC, et al. Novel Pyridazin-3 (2H) -one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity. ACS Med Chem Lett. 2022;13 (3) :463-469. Published 2022 Feb 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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