CYP121A1-IN-1
CYP121A1-IN-1 is a potent CYP121A1 inhibitor with favorable activity against Mycobacterium tuberculosis (H37Rv MIC90～6.25 μM, ～2.2 μg/mL) . CYP121A1-IN-1 can markedly reduce the production of mycocyclosin via inhibiting the CYP121A1 mediated turnover of cyclo (l-tyrosyl-l-tyrosyl) to mycocyclosin[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyp121a1-in-1.html
Solubility
10 mM in DMSO
Smiles
C12=CC=CC=C1N(C3=NC=CC(CCC4=CNC5=C4C=CC=C5)=N3)CCO2
Molecular Formula
C22H20N4O
Molecular Weight
356.42
References & Citations
[1]Frederickson M, et al. A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) . Eur J Med Chem. 2022;230:114105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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