CYP121A1-IN-1

CYP121A1-IN-1 is a potent CYP121A1 inhibitor with favorable activity against Mycobacterium tuberculosis (H37Rv MIC90～6.25 μM, ～2.2 μg/mL) . CYP121A1-IN-1 can markedly reduce the production of mycocyclosin via inhibiting the CYP121A1 mediated turnover of cyclo (l-tyrosyl-l-tyrosyl) to mycocyclosin[1].

Product Specifications

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyp121a1-in-1.html

Solubility

10 mM in DMSO

Smiles

C12=CC=CC=C1N(C3=NC=CC(CCC4=CNC5=C4C=CC=C5)=N3)CCO2

Molecular Formula

C22H20N4O

Molecular Weight

356.42

References & Citations

[1]Frederickson M, et al. A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) . Eur J Med Chem. 2022;230:114105.