ZLWH-23
ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM) . ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1].
Product Specifications
CAS Number
2765251-12-3
UNSPSC
12352005
Target
Cholinesterase (ChE) ; GSK-3
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zlwh-23.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C3=CC=NC(NC(C4CC4)=O)=C3N2)C=C1)NCCC5CCN(CC5)CC6=C(C=CC=C6)F
Molecular Formula
C30H32FN5O2
Molecular Weight
513.61
References & Citations
[1]Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; GSK-3β
Frequently Asked Questions
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