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ZLWH-23

ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM) . ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1].

Product Specifications

CAS Number

2765251-12-3

UNSPSC

12352005

Target

Cholinesterase (ChE) ; GSK-3

Type

Reference compound

Related Pathways

Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zlwh-23.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(C3=CC=NC(NC(C4CC4)=O)=C3N2)C=C1)NCCC5CCN(CC5)CC6=C(C=CC=C6)F

Molecular Formula

C30H32FN5O2

Molecular Weight

513.61

References & Citations

[1]Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; BChE; GSK-3β

Frequently Asked Questions

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