Xanthine oxidase-IN-4

Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].

Product Specifications

CAS Number

[2642137-96-8]

UNSPSC

12352005

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/xanthine-oxidase-in-4.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC(C2=NC=C3C(NNC3=O)=N2)=CC=C1OC(C)C

Molecular Formula

C15H13N5O2

Molecular Weight

295.30

References & Citations

[1]Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2- (4-alkoxy-3-cyanophenyl) pyrimidine-4/5-carboxylic acids and 6- (4-alkoxy-3-cyanophenyl) -1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086.