Tubulin polymerization-IN-5
Product Specifications
UNSPSC Description
Tubulin polymerization-IN-5 (compound 20q) is a potent tubulin inhibitor with potential anticancer activities. Tubulin polymerization-IN-5 can arrest ESCC cells at G2/M phase and cause cells apoptosis[1].
Target Antigen
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-5.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(N(C(CSC(N2CCN(CC2)C(OC(C)(C)C)=O)=S)=O)CC3=CC(O)=C(C=C3)OC)=CC(OC)=C1OC
Molecular Weight
621.77
References & Citations
[1]Sun YX, et al. Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities. Eur J Med Chem. 2022;229:114069.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144299/Tubulin-polymerization-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144299/
Clinical Information
No Development Reported
Curated Selection
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