Purine phosphoribosyltransferase-IN-2
Product Specifications
UNSPSC Description
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively[1].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/purine-phosphoribosyltransferase-in-2.html
Solubility
10 mM in DMSO
Smiles
O=P(O[Na])(O[Na])COC[C@@H](OC[C@H](P(O[Na])(O[Na])=O)O)CN1C=NC2=C1N=C(N)NC2=O
Molecular Weight
531.17
References & Citations
[1]Tomáš Klejch, et al. Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J Med Chem. 2022 Mar 10;65(5):4030-4057.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144296/Purine-phosphoribosyltransferase-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144296/
Clinical Information
No Development Reported
CAS Number
2784631-30-5
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