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Purine phosphoribosyltransferase-IN-2

Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf) ), Plasmodium vivax ((Pv) ) and Trypanosoma brucei ((Tbr) ) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively[1].

Product Specifications

CAS Number

[2784631-30-5]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/purine-phosphoribosyltransferase-in-2.html

Solubility

10 mM in DMSO

Smiles

O=P(O[Na])(O[Na])COC[C@@H](OC[C@H](P(O[Na])(O[Na])=O)O)CN1C=NC2=C1N=C(N)NC2=O

Molecular Formula

C11H15N5Na4O10P2

Molecular Weight

531.17

References & Citations

[1]Tomáš Klejch, et al. Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J Med Chem. 2022 Mar 10;65 (5) :4030-4057.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Plasmodium; Trypanosoma

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