LY3154885

LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM) . LY3154885 has an improved agent-agent interactions (DDI) risk profile[1].

Product Specifications

CAS Number

[2379422-72-5]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly3154885.html

Solubility

10 mM in DMSO

Smiles

CN1N=CC(C2=CC=CC3=C2C[C@H](CO)N(C(CC4=C(Cl)C=CC=C4Cl)=O)[C@H]3C)=C1

Molecular Formula

C23H23Cl2N3O2

Molecular Weight

444.35

References & Citations

[1]Junliang Hao, et al. Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile. J Med Chem. 2022 Mar 10;65 (5) :3786-3797.