CXCR4 antagonist 4
CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC50=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC50=7 nM) [1].
Product Specifications
CAS Number
2761009-30-5
UNSPSC
12352209
Target
CXCR; HIV
Type
Peptides
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cxcr4-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
FC1(F)CCC(N(CCCCN([C@@H]2C3=NC=CC=C3CCC2)C[C@@H]4NCC5=C(C4)N=CC=C5)C)CC1
Molecular Formula
C29H41F2N5
Molecular Weight
497.67
References & Citations
[1]Jecs E, et al. Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. J Med Chem. 2022, 65 (5) :4058-4084.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR4; HIV
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