MsbA-IN-5

MsbA-IN-5 (compound 40) is a potent and highly selective MsbA inhibitor with an IC50 value of 2 nM. MsbA-IN-5 has inhibitory activity against Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae with MICs of 12 μM, 12 μM and 25 μM, respectively. MsbA-IN-5 can be used for researching anti-Gram-negative bacteria[1].

Product Specifications

CAS Number

[2909443-06-5]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/msba-in-5.html

Solubility

10 mM in DMSO

Smiles

C[C@@H](C1=C(Cl)C=CC=C1Cl)OC2=CC=C3N=CC(/C=C/C4=NNN=N4)=C(C5CC5)C3=C2

Molecular Formula

C23H19Cl2N5O

Molecular Weight

452.34

References & Citations

[1]Verma VA, et al. Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J Med Chem. 2022;65 (5) :4085-4120.