BLK-IN-1
BLK-IN-1 (compound 1) is a selective and covalent inhibitor of B-Lymphoid tyrosine kinase (BLK) and BTK, with IC50s of 18.8 nM and 20.5 nM, respectively. BLK-IN-1 can be used for the research of cancer[1].
Product Specifications
CAS Number
1431727-00-2
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/blk-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CN=C(NC2=CC=CC(NC(C=C)=O)=C2)N=C1)C3=CC(NC(C4=CC=CC(C(F)(F)F)=C4)=O)=CC=C3C
Molecular Formula
C29H23F3N6O3
Molecular Weight
560.53
References & Citations
[1]Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK) . Eur J Med Chem. 2022 Feb 5;229:114051.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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