MsbA-IN-1

MsbA-IN-1 is a highly potent MsbA inhibitor with IC50 of 4 nM. MsbA-IN-1 has activity against wild-type E. coli with MIC of 79 μM. MsbA-IN-1 possesses sufficient permeability across the fully intact outer membrane of Gram-negative bacteria to inhibit MsbA[1].

Product Specifications

CAS Number

[2918334-61-7]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/msba-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C/C1=C(C2CC2)C3=CC(O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C)=CC=C3N=C1

Molecular Formula

C23H18Cl2FNO3

Molecular Weight

446.30

References & Citations

[1]Verma VA, Wang L, Labadie SS, et al. Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J Med Chem. 2022;65 (5) :4085-4120.