RIPK1-IN-12
RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].
Product Specifications
CAS Number
2173556-92-6
UNSPSC
12352209
Target
Necroptosis; RIP kinase
Type
Peptides
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk1-in-12.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1CCCCC1)NC2=CC(C3=CC=C4N=C(NC(C5CC5)=O)SC4=C3)=CN=C2C
Molecular Formula
C24H26N4O3S
Molecular Weight
450.55
References & Citations
[1]Li Z, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022, 228:114036.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
RIPK1
Frequently Asked Questions
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