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RIPK1-IN-11

RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM) . RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM) . Anti-inflammatory activity[1].

Product Specifications

CAS Number

2173557-02-1

UNSPSC

12352005

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ripk1-in-11.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1CCOCC1)NC2=CC(C3=CC=C4N=C(NC(C5CC5)=O)SC4=C3)=CN=C2C

Molecular Formula

C23H24N4O4S

Molecular Weight

452.53

References & Citations

[1]Li Z, Hao Y, Yang C, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022;228:114036.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK1

Frequently Asked Questions

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